Description

T-Butyldiethylchlorosilane is a highly versatile organosilicon reagent, specifically a chlorosilane derivative, widely used as a protecting agent for alcohols and other functional groups in complex organic synthesis. Its primary value lies in its steric bulk, which provides exceptional selectivity and stability for sensitive intermediates, particularly in multi-step pharmaceutical and agrochemical manufacturing. This compound is essential for R&D chemists and production specialists in the fine chemical, pharmaceutical, and advanced material sectors who require reliable and high-purity building blocks.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the selective protection of hydroxyl groups in the synthesis of active pharmaceutical ingredients (APIs) and complex natural products.
• Agrochemical Manufacturing: Used in the production of advanced pesticides and herbicides where selective protection/deprotection strategies are required.
• Peptide & Nucleotide Chemistry: Employed as a silylating agent to protect sensitive functional groups during solid-phase and solution-phase synthesis.
• Material Science Research: Serves as a precursor or surface modifying agent in the development of specialty silicones and silicon-based polymers.
• Academic & Industrial R&D: A fundamental tool in organic synthesis laboratories for developing new methodologies and constructing complex molecular architectures.

Basic Information

Product Name	T-Butyldiethylchlorosilane
CAS No.	107149-55-3
Molecular Formula	C8H19ClSi
Molecular Weight	178.77 g/mol
Synonyms	tert-Butyldiethylchlorosilane; TBDES-Cl; Chloro-tert-butyldiethylsilane; Diethyl-tert-butylchlorosilane; tert-Butyl(diethyl)chlorosilane; (tert-Butyl)diethylchlorosilane; 1-Chloro-1-(tert-butyl)-1-silapentane; 1,1-Diethyl-1-(tert-butyl)chlorosilane
EINECS	Contact for details

Quality Control

Our T-Butyldiethylchlorosilane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for demanding synthetic applications. Each lot undergoes comprehensive analytical testing, including GC, NMR, and titration, to verify identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support compliance with relevant regulatory frameworks for our customers' specific end-use requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.