Description

n-(3-(4-Azido-3-Iodophenyl)Propionyl)Succinimide is a specialized heterobifunctional crosslinking reagent designed for advanced bioconjugation and labeling applications. This compound is critical for researchers and manufacturers requiring precise, photoactivatable coupling of biomolecules, leveraging its azide group for click chemistry and its activated succinimide ester for amine-selective reactions. It is primarily utilized in the development of pharmaceuticals, diagnostic assays, and advanced materials where controlled molecular assembly is paramount.

Application

• Bioconjugation Reagent: For the site-specific crosslinking of proteins, peptides, and antibodies with other biomolecules or solid supports.
• Probe and Sensor Development: As a key building block in the synthesis of fluorescent, radioactive, or affinity probes for bioimaging and diagnostic applications.
• Pharmaceutical Research: In the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutic constructs.
• Materials Science: For the surface functionalization of nanoparticles, polymers, and hydrogels to introduce bio-recognition elements.
• Chemical Biology Studies: Enabling photoaffinity labeling and activity-based protein profiling to study protein function and interactions.
• Diagnostic Kit Manufacturing: Used in the production of lateral flow assays and ELISA kits for high-sensitivity detection.

Basic Information

Product Name	n-(3-(4-Azido-3-Iodophenyl)Propionyl)Succinimide
CAS No.	107082-23-5
Molecular Formula	C13H10IN4O3
Molecular Weight	412.15 g/mol
Synonyms	4-Azido-3-iodo-N-(2,5-dioxo-1-pyrrolidinyl)benzene propanamide; 3-(4-Azido-3-iodophenyl)propionic acid N-hydroxysuccinimide ester; N-Succinimidyl 3-(4-azido-3-iodophenyl)propionate; Heterobifunctional Crosslinker, Azido-NHS ester; Photoactivatable NHS Ester; NHS-PEG-Azide precursor; Iodophenyl Azide NHS Ester; CAS 107082-23-5
EINECS	Contact for details

Quality Control

Our n-(3-(4-Azido-3-Iodophenyl)Propionyl)Succinimide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional performance. We adhere to relevant Good Manufacturing Practice (GMP) principles for research chemicals, and specifications can be tailored to meet the requirements of pharmaceutical development and in-vitro diagnostic manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile
Functional Activity	Conforms (by conjugation test)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.