Description

tert-Butyl 4-(Aminomethyl)Benzoate is a versatile and high-purity chemical intermediate featuring both a protected carboxylic acid group and a reactive primary amine. This compound is crucial for the synthesis of complex molecules, offering chemists a stable, easily handled building block for constructing pharmacologically active scaffolds. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where its benzoate structure is incorporated into bioactive molecules.
• Peptide Mimetics & Linker Chemistry: The aminomethyl group serves as a convenient attachment point for constructing peptide-like structures or as a spacer/linker in bioconjugation and prodrug development.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic and functionalizable nature.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.
• Academic & Industrial R&D: Used in medicinal chemistry laboratories for hit-to-lead optimization and structure-activity relationship (SAR) studies.

Basic Information

Product Name	tert-Butyl 4-(Aminomethyl)Benzoate
CAS No.	107045-28-3
Molecular Formula	C12H17NO2
Molecular Weight	207.27 g/mol
Synonyms	4-(Aminomethyl)benzoic acid tert-butyl ester; tert-Butyl p-(aminomethyl)benzoate; Benzoic acid, 4-(aminomethyl)-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl 4-(aminomethyl)benzoate; 4-(tert-Butoxycarbonyl)benzylamine; Boc-Benzylamine (4-); 4-(Boc-aminomethyl)benzoic acid tert-butyl ester (common misnomer); p-(Aminomethyl)benzoic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Aminomethyl)Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We can support development projects with material produced under cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.