Description

[6As,(+)]-9α-Ethenyl-2,6,6Aα,7,8,9,10,10Aβ-Octahydro-10α-Isocyano-6,6,9-Trimethylnaphtho[1,2,3-Cd]Indole is a complex, high-value indole alkaloid derivative characterized by its unique isocyano functional group and stereochemistry. This compound matters as a sophisticated chemical building block and key intermediate for advanced research and synthesis. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing novel bioactive molecules, particularly in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, especially those targeting neurological or oncological pathways.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of complex alkaloid-based active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized in stereoselective reactions due to its defined chiral centers, aiding in the construction of other enantiomerically pure compounds.
• Chemical Biology Probes: Acts as a starting material for creating isocyanide-containing probes used to study biological interactions and enzyme mechanisms.
• Fine Chemical Synthesis: Functions as a specialized intermediate for producing other high-value, complex organic molecules for research and development.

Basic Information

Product Name	[6As,(+)]-9α-Ethenyl-2,6,6Aα,7,8,9,10,10Aβ-Octahydro-10α-Isocyano-6,6,9-Trimethylnaphtho[1,2,3-Cd]Indole
CAS No.	106928-30-7
Molecular Formula	C22H28N2
Molecular Weight	320.48 g/mol
Synonyms	(+)-9α-Ethenyl-10α-isocyano-6,6,9-trimethyl-2,3,6,6a,7,8,9,10a-octahydronaphtho[1,2,3-cd]indole; (6aS,10aR)-9-Ethenyl-10-isocyano-6,6,9-trimethyl-2,3,6a,7,8,9,10,10a-octahydronaphtho[1,2,3-cd]indole; (+)-9α-Vinyl-10α-isocyano-6,6,9-trimethyl-2,3,6,6a,7,8,9,10a-octahydronaphtho[1,2,3-cd]indole; Alkaloid derivative with isocyanide group; Isocyanide-functionalized indole alkaloid
EINECS	Contact for details

Quality Control

Our production of [6As,(+)]-9α-Ethenyl-2,6,6Aα,7,8,9,10,10Aβ-Octahydro-10α-Isocyano-6,6,9-Trimethylnaphtho[1,2,3-Cd]Indole adheres to stringent quality protocols suitable for research and development applications. All batches undergo rigorous analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to ensure traceability and support your critical R&D work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.