Description

[6As,(-)]-8β-Chloro-9β-Ethenyl-2,6,6Aα,7,8,9,10,10Aα-Octahydro-10α-Isocyano-6,6,9-Trimethylnaphtho[1,2,3-Cd]Indole is a complex, high-purity synthetic intermediate characterized by its unique polycyclic indole structure containing both chloro and isocyano functional groups. This compound is of significant value in advanced organic synthesis, particularly for constructing novel molecular scaffolds in pharmaceutical research and development. It serves as a critical building block for medicinal chemists and R&D laboratories focused on developing new active pharmaceutical ingredients (APIs) and exploring structure-activity relationships.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery programs.
• Medicinal Chemistry Research: Used as a versatile scaffold for lead optimization and the generation of compound libraries for high-throughput screening.
• Advanced Organic Synthesis: Employed in complex multi-step syntheses to introduce specific stereochemistry and functional groups into target molecules.
• Chemical Biology Probes: Serves as a starting material for developing labeled compounds or probes to study biological pathways and protein interactions.
• Contract Research & Development (CRO): Supplied to research organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Item	Details
Product Name	[6As,(-)]-8β-Chloro-9β-Ethenyl-2,6,6Aα,7,8,9,10,10Aα-Octahydro-10α-Isocyano-6,6,9-Trimethylnaphtho[1,2,3-Cd]Indole
CAS No.	106928-27-2
Molecular Formula	C22H27ClN2
Molecular Weight	354.92 g/mol
Synonyms	(-)-8β-Chloro-9β-ethenyl-10α-isocyano-6,6,9-trimethyl-2,6,6aα,7,8,9,10,10aα-octahydronaphtho[1,2,3-cd]indole; 8β-Chloro-9β-ethenyl-10α-isocyano-6,6,9-trimethyl-2,3,6,6aα,7,8,9,10,10aα-octahydronaphtho[1,2,3-cd]indole; 6aS,(-)-8β-Chloro-9β-ethenyl-2,3,6,6aα,7,8,9,10,10aα-octahydro-10α-isocyano-6,6,9-trimethylnaphtho[1,2,3-cd]indole; 6aS-(-)-8β-Chloro-9β-ethenyl-10α-isocyano-6,6,9-trimethyl-2,3,6,6aα,7,8,9,10,10aα-octahydronaphtho[1,2,3-cd]indole; 106928-27-2; Naphtho[1,2,3-cd]indole derivative
EINECS	Contact for details

Quality Control

Our [6As,(-)]-8β-Chloro-9β-Ethenyl-2,6,6Aα,7,8,9,10,10Aα-Octahydro-10α-Isocyano-6,6,9-Trimethylnaphtho[1,2,3-Cd]Indole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality systems are designed to meet the rigorous standards expected by the pharmaceutical R&D sector.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability. Keep the container tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.