Description

[6As,(+)]-9α-Ethenyl-2,6,6Aα,7,8,9,10,10Aα-Octahydro-10α-Isocyano-6,6,9-Trimethylnaphtho[1,2,3-Cd]Indole is a complex, high-purity alkaloid derivative characterized by its unique isocyano functional group and stereochemistry. This compound is valued for its role as a sophisticated chemical intermediate in advanced organic synthesis, particularly in the construction of complex nitrogen-containing molecular architectures. It is primarily sought after by pharmaceutical research and development teams and fine chemical manufacturers engaged in the synthesis of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in the development of central nervous system (CNS) agents and other therapeutic alkaloids.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its complex, polycyclic framework and reactive isocyano group.
• Asymmetric Synthesis: Serves as a valuable precursor or chiral template in catalytic and stoichiometric asymmetric synthesis for creating enantiomerically pure compounds.
• Natural Product Analog Synthesis: Employed in the semi-synthesis or total synthesis of complex natural products and their synthetic analogs for biological evaluation.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes to study biological pathways and protein interactions.
• Advanced Material Science: Potential use as a specialized monomer or precursor for high-performance polymers or functional materials with specific optical or electronic properties.

Basic Information

Item	Details
Product Name	[6As,(+)]-9α-Ethenyl-2,6,6Aα,7,8,9,10,10Aα-Octahydro-10α-Isocyano-6,6,9-Trimethylnaphtho[1,2,3-Cd]Indole
CAS No.	106928-26-1
Molecular Formula	C22H28N2
Molecular Weight	320.48 g/mol
Synonyms	(+)-9α-Ethenyl-10α-isocyano-6,6,9-trimethyloctahydronaphtho[1,2,3-cd]indole; (6aS,10aR)-9-Ethenyl-10-isocyano-6,6,9-trimethyl-1,2,6a,7,8,9,10,10a-octahydronaphtho[1,2,3-cd]indole; (+)-10α-Isocyano-9α-vinyl-6,6,9-trimethyl-1,2,6aα,7,8,9,10,10aα-octahydronaphtho[1,2,3-cd]indole; A complex isonitrile alkaloid derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific research or development project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container for extended periods to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.