Description

Halofantrine Hydrochloride is a synthetic antimalarial agent belonging to the phenanthrenemethanol class. It is valued for its specific activity against certain strains of *Plasmodium falciparum*, particularly in cases of uncomplicated malaria. This high-purity active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of antimalarial therapeutics and related pharmacological studies.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of antimalarial medications.
• Reference Standard in analytical laboratories for quality control and method validation.
• Biochemical Research for studying parasite biology and mechanisms of drug action.
• Pharmaceutical Development for creating new dosage forms and combination therapies.

Basic Information

Product Name	Halofantrine Hydrochloride
CAS No.	106927-11-1
Molecular Formula	C₂₆H₃₃Cl₂F₃NO • HCl
Molecular Weight	536.92 g/mol (for free base: 500.45)
Synonyms	Halofantrine HCl; (±)-Halofantrine Hydrochloride; 1,3-Dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol Hydrochloride; WR-171,669 Hydrochloride; Halfan (brand name); Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, hydrochloride (1:1); Halofantrinium Chloride
EINECS	Contact for details

Quality Control

Our Halofantrine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets high-grade pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.