Description

((3-(Bis(2-Chloroethyl)Amino)-4-Methylphenyl)Hydroxymethane)Bisphosphonic Acid is a specialized nitrogen-containing bisphosphonate compound of significant interest in advanced pharmaceutical research and development. Its molecular structure, featuring a chlorinated nitrogen mustard moiety linked to a bisphosphonic acid group, makes it a valuable intermediate for creating novel therapeutic agents. This compound is primarily utilized by research institutions and pharmaceutical companies focused on developing targeted treatments for bone-related disorders and oncology applications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nitrogen-containing bisphosphonate drugs for osteoporosis and Paget's disease.
• Oncology Research: Investigated for the development of targeted chemotherapeutic agents due to its potential bone-targeting and alkylating properties.
• Biochemical Probe: Used in academic and industrial research to study bone metabolism and hydroxyapatite binding mechanisms.
• Preclinical Development: Serves as a critical starting material for generating analogs in structure-activity relationship (SAR) studies.
• Radiopharmaceutical Precursor: Potential intermediate for developing bone-seeking diagnostic or therapeutic radiopharmaceuticals.

Basic Information

Product Name	((3-(Bis(2-Chloroethyl)Amino)-4-Methylphenyl)Hydroxymethane)Bisphosphonic Acid
CAS No.	106871-13-0
Molecular Formula	C₁₄H₂₁Cl₂N₂O₇P₂
Molecular Weight	453.17 g/mol
Synonyms	3-[Bis(2-chloroethyl)amino]-4-methylbenzylidene-1,1-bisphosphonic Acid; 3-[Bis(2-chloroethyl)amino]-4-methyl-α-(hydroxymethylene)bisphosphonic Acid; 3-(Bis(2-chloroethyl)amino)-4-methylbenzylidenebis(phosphonic acid); N,N-Bis(2-chloroethyl)-4-methyl-α-(hydroxymethylene)bisphosphonic aniline; Chloroethylamino Methylphenyl Bisphosphonate; Research Compound 106871-13-0
EINECS	Contact for details

Quality Control

Our ((3-(Bis(2-Chloroethyl)Amino)-4-Methylphenyl)Hydroxymethane)Bisphosphonic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and elemental analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.