Description

Tafenoquine Succinate is a high-purity pharmaceutical salt form of the antimalarial compound tafenoquine, identified by CAS NO 106635-81-8. It is a critical active pharmaceutical ingredient (API) valued for its long-acting prophylactic and radical cure properties against *Plasmodium vivax* malaria. This compound is essential for manufacturers in the global pharmaceutical industry developing and producing next-generation antimalarial medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in formulated antimalarial tablets for the prevention and treatment of malaria, particularly targeting the dormant hypnozoites of *P. vivax*.
• Clinical Research: Serves as a key reference standard and raw material in preclinical and clinical trials for new malaria therapeutics and combination therapies.
• Drug Development: Used in pharmaceutical R&D for studying pharmacokinetics, metabolism, and formulation stability of tafenoquine-based products.
• GMP Manufacturing: Supplied to certified facilities for the commercial-scale production of finished dosage forms under Good Manufacturing Practice (GMP) guidelines.

Basic Information

Product Name	Tafenoquine Succinate
CAS No.	106635-81-8
Molecular Formula	C₂₄H₂₈F₃N₅O₃ • C₄H₆O₄
Molecular Weight	581.59 g/mol (Free base: 463.51 g/mol)
Synonyms	WR 238605 Succinate; Tafenoquine hydrogen succinate; (RS)-Tafenoquine succinate; 8-[(4-Amino-1-methylbutyl)amino]-2,6-dimethoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline succinate; Etaquine succinate; SB-252263 succinate
EINECS	Contact for details

Quality Control

Our Tafenoquine Succinate is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality assurance protocols are designed to ensure identity, purity, strength, and composition, supporting regulatory filings. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results from tests including identification, assay, impurity profile, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.