Description

Ethyl (S)-(-)-2-(tert-Butyldimethylsilyloxy)Propionate is a high-value chiral building block and protected intermediate essential for asymmetric synthesis. Its primary value lies in providing a stereochemically defined, silicon-protected α-hydroxy ester moiety, enabling the controlled construction of complex molecules. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the production of active pharmaceutical ingredients (APIs), natural products, and specialty materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of β-hydroxy acid derivatives, statin side chains, and other bioactive molecules.
• Asymmetric Synthesis: Used in stereoselective aldol reactions, Reformatsky-type reactions, and nucleophilic additions to construct chiral centers.
• Natural Product Synthesis: Building block for the total synthesis of complex natural products containing polyketide or polypropionate segments.
• Agrochemical Research: Intermediate in the development of chiral herbicides, fungicides, and plant growth regulators.
• Material Science: Precursor for chiral monomers in polymer chemistry and liquid crystal research.
• Process Chemistry Development: Scalable intermediate for optimizing commercial routes to enantiomerically pure compounds under GMP conditions.

Basic Information

Product Name	Ethyl (S)-(-)-2-(tert-Butyldimethylsilyloxy)Propionate
CAS No.	106513-42-2
Molecular Formula	C11H24O3Si
Molecular Weight	232.40 g/mol
Synonyms	(S)-(-)-Ethyl 2-[(tert-Butyldimethylsilyl)oxy]propionate; (S)-Ethyl 2-(tert-Butyldimethylsiloxy)propanoate; Ethyl (S)-2-((tert-Butyldimethylsilyl)oxy)propanoate; (S)-2-(tert-Butyldimethylsilyloxy)propionic Acid Ethyl Ester; TBDMS-(S)-Lactate Ethyl Ester; (S)-Ethyl O-(tert-Butyldimethylsilyl)lactate; (S)-(-)-2-(TBDMSO)Propionic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl (S)-(-)-2-(tert-Butyldimethylsilyloxy)Propionate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. We provide comprehensive analytical data including HPLC purity, chiral GC/HPLC for enantiomeric excess (ee), and identity confirmation (NMR, IR). Certificates of Analysis (COA) detailing all specifications are available for every batch. Our quality commitment supports applications requiring GMP starting materials and compliance with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture. For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral GC/HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.