Description

(2R)-(-)-Glycidyl 4-Nitrobenzoate is a high-purity chiral epoxide derivative, serving as a critical chiral building block and resolving agent in asymmetric synthesis. Its enantiomeric purity makes it invaluable for the preparation of optically active pharmaceutical intermediates and fine chemicals. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key precursor for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drug candidates.
• Asymmetric Catalyst and Ligand Preparation: Used in the development and synthesis of chiral catalysts and ligands for enantioselective reactions.
• Chiral Resolution Agent: Employed for the separation of racemic mixtures of acids, amines, and alcohols via diastereomeric salt or ester formation.
• Agrochemical Intermediate: Utilized in the production of chiral herbicides, fungicides, and plant growth regulators where specific stereochemistry impacts biological activity.
• Polymer Modification: Acts as a reactive monomer for introducing chiral epoxide functionalities into polymers, potentially modifying their physical and optical properties.
• Academic and Industrial R&D: Serves as a standard and reagent in methodological development for new asymmetric synthetic routes.

Basic Information

Product Name	(2R)-(-)-Glycidyl 4-Nitrobenzoate
CAS No.	106268-95-5
Molecular Formula	C10H9NO5
Molecular Weight	223.18 g/mol
Synonyms	(-)-(R)-Glycidyl 4-Nitrobenzoate; (R)-(-)-Glycidyl p-Nitrobenzoate; (2R)-Oxiran-2-ylmethyl 4-nitrobenzoate; (R)-Glycidyl 4-Nitrobenzoate; p-Nitrobenzoic Acid (R)-Glycidyl Ester; (R)-Epoxypropyl 4-Nitrobenzoate; (R)-1,2-Epoxy-3-(4-nitrobenzoyloxy)propane; (R)-GNPB
EINECS	Contact for details

Quality Control

Our (2R)-(-)-Glycidyl 4-Nitrobenzoate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) providing specifications for identity, purity, enantiomeric excess, and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability and enantiomeric purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.