Description

Proline, 4,4-Dimethyl-, Methyl Ester (9Ci) is a specialized proline derivative, a key chiral building block in advanced organic synthesis. This compound is valued for its role in introducing sterically hindered proline motifs, which are crucial for modulating the conformation and biological activity of target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, protease inhibitors, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of new drug candidates, particularly for non-standard amino acid incorporation.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce constrained, dimethyl-substituted proline analogs that influence peptide backbone conformation and stability.
• Protease Inhibitor Design: Acts as a core structural component in the design of inhibitors targeting specific enzymes like prolyl oligopeptidase.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to construct complex chiral centers.
• Biochemical Research: Utilized as a standard or reagent in metabolic pathway studies and enzyme-substrate interaction research.
• Agrochemical Synthesis: Potential intermediate in the synthesis of advanced, chiral active ingredients for crop protection.

Basic Information

Product Name	Proline, 4,4-Dimethyl-, Methyl Ester (9Ci)
CAS No.	106230-19-7
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	L-Proline, 4,4-dimethyl-, methyl ester; Methyl 4,4-dimethyl-L-prolinate; 4,4-Dimethyl-L-proline methyl ester; Methyl (2S)-4,4-dimethylpyrrolidine-2-carboxylate; (S)-Methyl 4,4-dimethylpyrrolidine-2-carboxylate; 4,4-Dimethylproline methyl ester; Proline derivative, 4,4-dimethyl methyl ester
EINECS	Contact for details

Quality Control

Our Proline, 4,4-Dimethyl-, Methyl Ester (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is compatible with strong acids and organic solvents but should be kept away from incompatible materials. Keep the container tightly sealed when not in use to maintain quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.