Description

(2S)-3-([tert-Butyl(Dimethyl)Silyl]Oxy)-2-Methylpropan-1-Ol CAS NO 105859-45-8 is a high-purity, chiral protected alcohol intermediate essential for advanced organic synthesis. Its primary value lies in providing a versatile, enantiomerically pure building block for constructing complex pharmaceutical and agrochemical molecules. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, fine chemical, and biotechnology industries for the synthesis of active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly for introducing stereocenters.
• Asymmetric Synthesis: Used in the preparation of enantiomerically pure compounds for applications in medicinal chemistry and catalysis.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) group protects the alcohol functionality during complex synthetic sequences, allowing for selective reactions at other sites.
• Natural Product Synthesis: Employed in the total synthesis of complex natural products where precise stereochemical control is required.
• Agrochemical Research: Serves as a building block for developing novel, chiral active ingredients with specific biological activity.
• Ligand and Catalyst Preparation: Used to synthesize chiral ligands for asymmetric catalysis and metal complexes.

Basic Information

Product Name	(2S)-3-([tert-Butyl(Dimethyl)Silyl]Oxy)-2-Methylpropan-1-Ol
CAS No.	105859-45-8
Molecular Formula	C10H24O2Si
Molecular Weight	204.39 g/mol
Synonyms	(2S)-3-[(tert-Butyldimethylsilyl)oxy]-2-methyl-1-propanol; (S)-3-((tert-Butyldimethylsilyl)oxy)-2-methylpropan-1-ol; (S)-TBDMS-Protected 2-Methyl-1,3-propanediol; (S)-3-(tert-Butyldimethylsiloxy)-2-methylpropanol; (S)-1,3-Propanediol, 2-methyl-, 3-(1,1-dimethylethyl)dimethylsilyl ether, (2S)-; TBDMS ether of (S)-2-Methyl-1,3-propanediol; Chiral TBDMS Alcohol Intermediate
EINECS	Contact for details

Quality Control

Our (2S)-3-([tert-Butyl(Dimethyl)Silyl]Oxy)-2-Methylpropan-1-Ol is manufactured under strict quality control protocols to ensure high enantiomeric excess (ee) and chemical purity suitable for sensitive synthetic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical assay, and impurity profile. We adhere to cGMP guidelines where applicable to support our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.