Description

(2R)-Methyl 3-[(tert-Butyldimethylsilyl)Oxy]-2-Methylpropionate is a high-purity chiral synthon featuring a protected hydroxy group, essential for advanced asymmetric synthesis. This compound matters as a critical building block for pharmaceutical intermediates, enabling the precise construction of complex molecules with defined stereochemistry. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug molecules, particularly for APIs requiring specific (R)-configuration.
• Asymmetric Synthesis: Used in stereoselective reactions to introduce chiral centers with high enantiomeric purity.
• Peptidomimetics & Pro-drug Synthesis: Serves as a protected hydroxy acid derivative for constructing modified peptide backbones and designing pro-drugs.
• Natural Product Synthesis: Employed in the total synthesis of natural products where the (2R)-methyl-3-hydroxypropionate moiety is a structural component.
• Ligand & Catalyst Development: Acts as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Polymer Chemistry: Can be utilized to introduce chiral, functionalized side chains into specialty polymers.

Basic Information

Product Name	(2R)-Methyl 3-[(tert-Butyldimethylsilyl)Oxy]-2-Methylpropionate
CAS No.	105859-44-7
Molecular Formula	C12H26O3Si
Molecular Weight	246.42 g/mol
Synonyms	(R)-Methyl 3-((tert-Butyldimethylsilyl)oxy)-2-methylpropanoate; Methyl (2R)-3-[(tert-Butyldimethylsilyl)oxy]-2-methylpropionate; (R)-3-(tert-Butyldimethylsilyloxy)-2-methylpropionic Acid Methyl Ester; (R)-Methyl 3-(TBDMSO)-2-methylpropionate; (2R)-2-Methyl-3-[(2-methyl-2-propanyl)dimethylsilyl]oxy]propanoic Acid Methyl Ester; (R)-Methyl 3-(tert-butyldimethylsiloxy)-2-methylpropanoate; TBDMS Protected (R)-3-Hydroxy-2-methylpropionate Methyl Ester
EINECS	Contact for details

Quality Control

Our (2R)-Methyl 3-[(tert-Butyldimethylsilyl)Oxy]-2-Methylpropionate is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC, NMR, and GC, to confirm identity, purity, and the absence of critical impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.