Description

n-Methoxy-N,o-Bis(Trimethylsilyl)Carbamate is a specialized organosilicon reagent primarily used as a versatile silylating agent and protecting group in complex organic synthesis. Its value lies in its ability to introduce the trimethylsilyl (TMS) group under mild conditions, facilitating the synthesis of sensitive intermediates. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for constructing novel molecules.

Application

• Pharmaceutical Intermediate Synthesis: Used as a key reagent in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for protecting hydroxyl or carboxyl groups.
• Agrochemical Research: Employed in the development of novel pesticides and herbicides where selective silylation is required for functional group manipulation.
• Peptide Chemistry: Acts as a protecting agent for amino acids during solid-phase peptide synthesis (SPPS) to prevent unwanted side reactions.
• Natural Product Synthesis: Facilitates the construction of complex natural product scaffolds by protecting sensitive functional groups in multi-step sequences.
• Material Science Precursor: Serves as a precursor or modifying agent in the synthesis of silicon-containing polymers and advanced hybrid materials.
• Analytical Derivatization: Used to derivative polar compounds for Gas Chromatography (GC) or Mass Spectrometry (MS) analysis, improving their volatility and detection.

Basic Information

Product Name	n-Methoxy-N,o-Bis(Trimethylsilyl)Carbamate
CAS No.	105532-86-3
Molecular Formula	C9H23NO3Si2
Molecular Weight	249.45 g/mol
Synonyms	Carbamic acid, N-methoxy-, N,O-bis(trimethylsilyl) ester; N-Methoxy-N,O-bis(trimethylsilyl)carbamate; BTMSC; Bis(trimethylsilyl) N-methoxycarbamate; (Methoxycarbonyloxy)trimethylsilane (related); TMS-N-methoxycarbamate; N,O-Bis-TMS-methoxycarbamate; Silylating Agent B-1790
EINECS	Contact for details

Quality Control

Our n-Methoxy-N,o-Bis(Trimethylsilyl)Carbamate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and process development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) after opening to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.