Description

Propanoic Acid, 2-Methyl-, 5-Acetyl-5,6,7,9-Tetrahydro-9-Oxo-3-(Trimethylsilyl)-3H-Imidazo[1,2-A]Purine-6,7-Diyl Ester (9Ci) is a sophisticated, high-purity organic compound featuring a complex fused heterocyclic structure with a trimethylsilyl protecting group. This compound matters as a critical advanced pharmaceutical intermediate or research chemical used in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of purine-based therapeutics. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for targeted drug discovery and process optimization.

Application

• Key Intermediate in Nucleoside/Nucleotide Analog Synthesis: Serves as a crucial building block for developing novel antiviral or anticancer agents.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Employed in scaling up synthetic routes for new chemical entities (NCEs) under GMP-like conditions.
• Biochemical Research: Potential use as a probe or inhibitor in enzymatic studies targeting purine-binding sites.
• Fine Chemical Synthesis: Utilized for the preparation of complex, high-value specialty chemicals for advanced material science.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for custom synthesis projects.

Basic Information

Product Name	Propanoic Acid, 2-Methyl-, 5-Acetyl-5,6,7,9-Tetrahydro-9-Oxo-3-(Trimethylsilyl)-3H-Imidazo[1,2-A]Purine-6,7-Diyl Ester (9Ci)
CAS No.	105528-84-5
Molecular Formula	C20H27N5O5Si
Molecular Weight	445.55 g/mol
Synonyms	5-Acetyl-5,6,7,9-tetrahydro-9-oxo-3-(trimethylsilyl)-3H-imidazo[1,2-a]purine-6,7-diyl 2-methylpropanoate; 3H-Imidazo[1,2-a]purine-6,7-diol, 5-acetyl-5,6,7,9-tetrahydro-9-oxo-3-(trimethylsilyl)-, 6,7-bis(2-methylpropanoate); 2-Methylpropanoic acid, 5-acetyl-5,6,7,9-tetrahydro-9-oxo-3-(trimethylsilyl)-3H-imidazo[1,2-a]purine-6,7-diyl ester; TMS-protected imidazopurine diester; Isovaleric acid derivative of acetyl-tetrahydro-oxo-trimethylsilylimidazopurine.
EINECS	Contact for details

Quality Control

Our high-purity chemical intermediates are manufactured under strict quality management systems. Each batch of Propanoic Acid, 2-Methyl-, 5-Acetyl-5,6,7,9-Tetrahydro-9-Oxo-3-(Trimethylsilyl)-3H-Imidazo[1,2-A]Purine-6,7-Diyl Ester (9Ci) undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets stringent specifications for research and development use. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be sensitive to moisture and should be handled under inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.