Description

4-tert-Butyldimethylsilyloxybenzeneacetic Acid Methyl Ester is a high-value, protected synthetic intermediate crucial for advanced organic synthesis. This compound matters because it provides a stable, silyl-protected phenolic moiety, enabling precise and selective chemical transformations in complex molecule assembly. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, particularly those containing phenolic or benzyl alcohol functional groups.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where protected intermediates are required for selective reactions.
• Peptide Chemistry: Serves as a protected precursor for introducing tyrosine-like or other phenolic amino acid derivatives into peptide chains.
• Material Science Research: Acts as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.
• Academic & Industrial R&D: A versatile reagent for methodological development in organic synthesis, including cross-coupling and protection/deprotection strategy studies.

Basic Information

Product Name	4-tert-Butyldimethylsilyloxybenzeneacetic Acid Methyl Ester
CAS No.	105460-59-1
Molecular Formula	C15H24O3Si
Molecular Weight	280.44 g/mol
Synonyms	Methyl (4-((tert-butyldimethylsilyl)oxy)phenyl)acetate; Methyl 2-(4-((tert-Butyldimethylsilyl)oxy)phenyl)acetate; 4-(tert-Butyldimethylsiloxy)phenylacetic Acid Methyl Ester; 4-TBDMS-O-Phenylacetic Acid Methyl Ester; p-(tert-Butyldimethylsilyloxy)benzeneacetic Acid Methyl Ester; Methyl p-((tert-Butyldimethylsilyl)oxy)phenylacetate; TBDMS-Protected Methyl Tyrosinate Derivative
EINECS	Contact for details

Quality Control

Our 4-tert-Butyldimethylsilyloxybenzeneacetic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.