Description

2-(tert-Butyldimethylsilyloxy)Acetic Acid is a versatile silyl-protected carboxylic acid derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a protected glycolic acid equivalent, enabling the controlled introduction of a hydroxymethylene unit under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, particularly for the synthesis of complex molecules, active pharmaceutical ingredients (APIs), and novel materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), prodrugs, and complex drug candidates.
• Peptide & Oligonucleotide Synthesis: Used as a protected linker or spacer molecule in solid-phase and solution-phase synthesis.
• Agrochemical Development: Intermediate in the production of advanced herbicides, fungicides, and plant growth regulators.
• Material Science: Precursor for functionalized polymers, surface modifiers, and specialty coatings.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research.
• Fine Chemical Synthesis: Employed in the production of flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	2-(tert-Butyldimethylsilyloxy)Acetic Acid
CAS No.	105459-05-0
Molecular Formula	C8H18O3Si
Molecular Weight	190.31 g/mol
Synonyms	2-[(tert-Butyldimethylsilyl)oxy]acetic Acid; (tert-Butyldimethylsiloxy)acetic Acid; TBDMS-Glycolic Acid; Acetic Acid, 2-[(1,1-Dimethylethyl)dimethylsilyl]oxy]-; 2-(TBDMSO)Acetic Acid; Glycolic Acid O-tert-Butyldimethylsilyl Ether; O-(tert-Butyldimethylsilyl)glycolic Acid
EINECS	Contact for details

Quality Control

Our 2-(tert-Butyldimethylsilyloxy)Acetic Acid is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC, NMR, and GC analysis, to verify identity and purity. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.