Description

Methyl5'-Hydroxy-5,5-Dimethyl-3',3'A,4',6'A-Tetrahydro-1'H-Spiro[1,3-Dioxane-2,2'-Pentalene]-6'-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical industries for process development and commercial-scale production.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of complex drug molecules, especially those with spirocyclic or fused ring systems.
• Organic Synthesis Building Block: Used in advanced organic chemistry for constructing intricate molecular frameworks in academic and industrial R&D settings.
• Medicinal Chemistry Research: Employed in the discovery and optimization of new chemical entities (NCEs) for various therapeutic targets.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals requiring high structural precision and purity.

Basic Information

Product Name	Methyl5'-Hydroxy-5,5-Dimethyl-3',3'A,4',6'A-Tetrahydro-1'H-Spiro[1,3-Dioxane-2,2'-Pentalene]-6'-Carboxylate
CAS No.	105448-66-6
Molecular Formula	C15H22O5
Molecular Weight	282.33 g/mol
Synonyms	Methyl 5'-hydroxy-5,5-dimethyl-3',3'a,4',6'a-tetrahydro-1'H-spiro[1,3-dioxane-2,2'-pentalene]-6'-carboxylate; 1'H-Spiro[1,3-dioxane-2,2'-pentalene]-6'-carboxylic acid, 5'-hydroxy-5,5-dimethyl-3',3'a,4',6'a-tetrahydro-, methyl ester; Methyl 5-hydroxy-5,5-dimethyl-3a,4,6,6a-tetrahydro-1H-spiro[1,3-dioxane-2,2'-pentalene]-6-carboxylate (alternative numbering); Spiro[1,3-dioxane-2,2'-pentalene] carboxylate derivative.
EINECS	Contact for details

Quality Control

Our Methyl5'-Hydroxy-5,5-Dimethyl-3',3'A,4',6'A-Tetrahydro-1'H-Spiro[1,3-Dioxane-2,2'-Pentalene]-6'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.