Description

m-Peg3-4-Nitrophenyl Carbonate is a high-purity, functionalized PEG derivative designed for advanced bioconjugation and pharmaceutical research. This compound serves as a critical reagent for the controlled, covalent attachment of bioactive molecules, enabling the development of targeted drug delivery systems and diagnostic agents. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for the synthesis of antibody-drug conjugates (ADCs), peptide modifications, and polymer-drug constructs.

Application

• Bioconjugation Reagent: A key intermediate for the site-specific modification of proteins, peptides, and antibodies to create stable conjugates.
• Antibody-Drug Conjugate (ADC) Development: Used to link cytotoxic payloads to monoclonal antibodies via a cleavable or non-cleavable PEG spacer, enhancing solubility and pharmacokinetics.
• Polymer Therapeutics: Serves as a building block for synthesizing functionalized PEG-based polymers for drug delivery and tissue engineering.
• Diagnostic Probe Synthesis: Facilitates the labeling of biomolecules with fluorophores or other reporter groups for imaging and diagnostic applications.
• Crosslinking Agent: Employed in the preparation of hydrogels and biomaterial scaffolds where controlled chemical crosslinking is required.
• Prodrug Synthesis: Enables the design of prodrugs with improved solubility and targeted release profiles through PEGylation strategies.

Basic Information

Product Name	m-Peg3-4-Nitrophenyl Carbonate
CAS No.	105108-59-6
Molecular Formula	C16H21NO9
Molecular Weight	371.34 g/mol
Synonyms	3-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)propyl (4-nitrophenyl) carbonate; mPEG3-4-Nitrophenyl Carbonate; 4-Nitrophenyl Carbonate PEG3; (4-Nitrophenyl) Carbonate-PEG3-alcohol; PEG3-4-NPC; 4-NPC-PEG3-OH; 1-(2-(2-(3-((4-Nitrophenoxy)carbonyloxy)propoxy)ethoxy)ethoxy)ethan-2-ol; 4-Nitrophenyl Chloroformate PEG3 Derivative
EINECS	Contact for details

Quality Control

Our m-Peg3-4-Nitrophenyl Carbonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant regulatory frameworks, including ICH guidelines, for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
4-Nitrophenol (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.