Description

2-Mercapto-6-Phenyl-4-(Trifluoromethyl)Nicotinonitrile is a specialized heterocyclic building block featuring a nicotinonitrile core substituted with phenyl, trifluoromethyl, and mercapto functional groups. This compound matters as a high-value synthetic intermediate, prized for its unique trifluoromethyl group which imparts desirable properties like enhanced metabolic stability and lipophilicity to final molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block for the research and development of new drug candidates, particularly in kinase inhibitor and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in creating advanced active ingredients for crop protection products, leveraging the trifluoromethyl group for improved efficacy and environmental profile.
• Material Science Research: Serves as a precursor for functionalized heterocyclic compounds used in organic electronics and advanced polymer research.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated heterocyclic architectures.

Basic Information

Product Name	2-Mercapto-6-Phenyl-4-(Trifluoromethyl)Nicotinonitrile
CAS No.	104960-49-8
Molecular Formula	C13H7F3N2S
Molecular Weight	280.27 g/mol
Synonyms	4-(Trifluoromethyl)-6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile; 2-Mercapto-6-phenyl-4-trifluoromethylnicotinonitrile; 6-Phenyl-4-(trifluoromethyl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile; 2-Thioxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 2-Mercapto-4-(trifluoromethyl)-6-phenylnicotinonitrile; 2-Mercapto-6-phenyl-4-(trifluoromethyl)-3-cyanopyridine; 2-Thio-6-phenyl-4-(trifluoromethyl)nicotinonitrile
EINECS	Contact for details

Quality Control

Our 2-Mercapto-6-Phenyl-4-(Trifluoromethyl)Nicotinonitrile is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.