Description

(2,5-Dioxopyrrolidin-1-yl) Heptanoate is a specialized active ester reagent widely used in organic synthesis and bioconjugation chemistry. Its core value lies in its ability to efficiently form amide bonds under mild conditions, making it a critical tool for coupling carboxylic acids to amines. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors. It is particularly valuable for peptide synthesis, protein labeling, and the preparation of polymer conjugates where high coupling efficiency and selectivity are required.

Application

• Peptide Synthesis: Acts as a key coupling agent for the formation of amide bonds in solid-phase and solution-phase peptide synthesis.
• Bioconjugation & Protein Labeling: Used to attach fluorescent dyes, biotin, polyethylene glycol (PEG), or other functional molecules to proteins, antibodies, and other biomolecules.
• Polymer Functionalization: Enables the modification of polymer backbones with bioactive ligands or other chemical groups for advanced material development.
• Prodrug Synthesis: Employed in the design and synthesis of prodrugs by linking active pharmaceutical ingredients (APIs) to promoieties for controlled release.
• Cross-linking Agent: Serves as a homobifunctional cross-linker for connecting amine-containing molecules in biochemical and material science applications.
• Chemical Intermediate: A versatile building block for the synthesis of more complex N-hydroxysuccinimide (NHS) ester derivatives and other fine chemicals.

Basic Information

Product Name	(2,5-Dioxopyrrolidin-1-yl) Heptanoate
CAS No.	104943-22-8
Molecular Formula	C11H17NO4
Molecular Weight	227.26 g/mol
Synonyms	Heptanoic Acid N-Hydroxysuccinimide Ester; N-Hydroxysuccinimidyl Heptanoate; NHS-Heptanoate; 1-[(1-Oxoheptyl)oxy]-2,5-pyrrolidinedione; N-Succinimidyl Heptanoate; Heptanoic Acid Succinimidyl Ester; HSE; Succinimidyl Heptanoate
EINECS	Contact for details

Quality Control

Our (2,5-Dioxopyrrolidin-1-yl) Heptanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR and IR for structural confirmation, and loss on drying for moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the reagent meets the high standards required for sensitive applications in research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent hydrolysis and maintain stability. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.