Description

(R)-2-Amino-3-(4-Fluorophenyl)Propionicacidethylester CAS NO 104880-95-7 is a high-purity, single-enantiomer chiral building block essential for advanced pharmaceutical synthesis. This compound serves as a critical intermediate in the development of active pharmaceutical ingredients (APIs), particularly those targeting neurological and psychiatric disorders. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) targeted therapies.
• Peptidomimetic Research: Used in the design and construction of peptide analogs and mimetics for drug discovery programs.
• Asymmetric Synthesis: Employed as a starting material or reagent in stereoselective chemical reactions to introduce chiral centers.
• API Development: Integral to the production route of complex Active Pharmaceutical Ingredients requiring the (R)-enantiomer of fluorinated phenylalanine derivatives.
• Biochemical Research: Utilized in studies of enzyme inhibition, receptor binding, and metabolic pathways involving amino acid analogs.
• Preclinical & Clinical Trial Material: Sourced for the production of batches intended for non-clinical and clinical studies under GMP guidelines.

Basic Information

Product Name	(R)-2-Amino-3-(4-Fluorophenyl)Propionicacidethylester
CAS No.	104880-95-7
Molecular Formula	C11H14FNO2
Molecular Weight	211.23 g/mol
Synonyms	(R)-Ethyl 2-amino-3-(4-fluorophenyl)propanoate; D-4-Fluorophenylalanine ethyl ester; (R)-4-Fluoro-DL-phenylalanine ethyl ester; Ethyl (R)-2-amino-3-(4-fluorophenyl)propionate; (R)-2-Amino-3-(p-fluorophenyl)propionic acid ethyl ester; F-D-Phe-OEt; (R)-F-Phe-OEt
EINECS	Contact for details

Quality Control

Our (R)-2-Amino-3-(4-Fluorophenyl)Propionicacidethylester is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.