Description

Boc-Homoser(Me)-OH is a protected derivative of the non-proteinogenic amino acid homoserine, specifically featuring a tert-butoxycarbonyl (Boc) protecting group on the amine and a methyl ester on the side-chain hydroxyl. This compound is a crucial building block in solid-phase and solution-phase peptide synthesis, offering orthogonal protection strategies for complex molecule assembly. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers developing novel therapeutic peptides and biochemical probes.

Application

• Peptide Synthesis Intermediate: A key protected amino acid derivative for the controlled synthesis of peptides containing homoserine or its analogs.
• Pharmaceutical Research: Used in the development and production of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or cross-linkers used in biochemical and diagnostic applications.
• Combinatorial Chemistry: Employed in libraries for drug discovery to introduce specific structural and functional diversity.
• Academic & Industrial R&D: Fundamental research tool in organic chemistry, medicinal chemistry, and chemical biology laboratories.

Basic Information

Product Name	Boc-Homoser(Me)-OH
CAS No.	104839-08-9
Molecular Formula	C10H19NO5
Molecular Weight	233.26 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-4-methoxy-4-oxobutanoic acid; N-(tert-Butoxycarbonyl)-O-methyl-L-homoserine; Boc-L-homoserine(Me)-OH; Boc-Homoser(OMe)-OH; N-Boc-O-methyl-L-homoserine; Boc-Hse(OMe)-OH; tert-Butyl ((3S)-3-methoxy-1,3-dioxo-1-(oxolan-2-yl)propyl)carbamate (related form); L-Homoserine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our Boc-Homoser(Me)-OH is manufactured under strict quality systems to ensure batch-to-batch consistency for research and production. Quality is verified through comprehensive analytical techniques including HPLC for purity and chiral analysis to confirm enantiomeric integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key specifications such as assay, optical rotation, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.