Description

(1R,4R)-Ethyl 4-(Hydroxymethyl)Cyclohexanecarboxylate is a high-purity chiral building block of significant value in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecules with defined stereochemistry, which is critical for efficacy in active pharmaceutical ingredients (APIs) and specialty chemicals. It is primarily needed by research and development teams, process chemists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel, stereoselective compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced, stereospecific pesticides and herbicides where biological activity is enantiomer-dependent.
• Liquid Crystal & Advanced Material Precursor: Serves as a building block for chiral dopants and other functional materials requiring rigid, substituted cyclohexane frameworks.
• Asymmetric Catalysis Ligand Synthesis: Employed in the development of novel chiral ligands and organocatalysts for stereoselective transformations.
• Fragrance & Flavor Chemistry: Utilized as an intermediate for creating stereochemically pure aroma chemicals with specific olfactory profiles.
• Academic & Industrial R&D: A valuable reagent for methodological development in synthetic organic chemistry and process optimization studies.

Basic Information

Product Name	(1R,4R)-Ethyl 4-(Hydroxymethyl)Cyclohexanecarboxylate
CAS No.	104802-52-0
Molecular Formula	C10H18O3
Molecular Weight	186.25 g/mol
Synonyms	trans-Ethyl 4-(Hydroxymethyl)cyclohexanecarboxylate; (1R,4R)-4-(Hydroxymethyl)cyclohexanecarboxylic Acid Ethyl Ester; Ethyl (1R,4R)-4-(Hydroxymethyl)cyclohexanecarboxylate; trans-4-(Hydroxymethyl)cyclohexanecarboxylic Acid Ethyl Ester; (R,R)-Ethyl 4-(Hydroxymethyl)cyclohexanecarboxylate; 4-(Hydroxymethyl)cyclohexanecarboxylic Acid Ethyl Ester, trans-; Ethyl trans-4-(Hydroxymethyl)cyclohexanecarboxylate
EINECS	Contact for details

Quality Control

Our (1R,4R)-Ethyl 4-(Hydroxymethyl)Cyclohexanecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.