Description

D-Alanine, 2-Hydroxy-1-(Hydroxymethyl)Ethyl Ester (9Ci) is a specialized chiral building block and ester derivative of D-alanine, offering a unique combination of a non-natural D-amino acid configuration with a glycerol-like side chain. This molecular architecture makes it a valuable intermediate for the synthesis of complex, biologically active compounds where stereochemistry and specific functionalization are critical. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptidomimetic drug discovery, prodrug development, and the creation of novel materials for biomedical applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel peptide-based therapeutics, antibiotics, and enzyme inhibitors.
• Prodrug Design: Utilized to create ester prodrugs of active pharmaceutical ingredients (APIs) to improve solubility, bioavailability, or targeted delivery.
• Bioconjugation & Linker Chemistry: Serves as a versatile spacer or linker molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving D-amino acid metabolizing enzymes.
• Material Science: A potential monomer or modifier for synthesizing functional polymers with specific chiral or hydrophilic properties.
• Asymmetric Synthesis: Acts as a chiral auxiliary or building block in stereoselective organic synthesis.

Basic Information

Product Name	D-Alanine, 2-Hydroxy-1-(Hydroxymethyl)Ethyl Ester (9Ci)
CAS No.	104537-90-8
Molecular Formula	C6H13NO4
Molecular Weight	163.17 g/mol
Synonyms	D-Alanine 2,3-dihydroxypropyl ester; (R)-2-Aminopropionic acid 2,3-dihydroxypropyl ester; Glycerol 1-(D-alaninate); 2,3-Dihydroxypropyl D-alaninate; Propanoic acid, 2-amino-, (2R)-, 2,3-dihydroxypropyl ester; D-Alanin-2,3-dihydroxypropylester; (R)-2,3-Dihydroxypropyl 2-aminopropanoate
EINECS	Contact for details

Quality Control

Our D-Alanine, 2-Hydroxy-1-(Hydroxymethyl)Ethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the exacting standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.