Description

(S)-3-Boc-Amino-γ-Butyrolactone CAS NO 104227-71-6 is a high-purity chiral building block and protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical intermediate in the production of complex pharmaceutical molecules, offering a versatile handle for stereoselective transformations. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), peptidomimetics, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of various drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in the construction of complex peptides and peptidomimetics, where the Boc-protected amino group and lactone functionality are strategically employed.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric reactions to introduce stereogenic centers.
• Protease Inhibitor Development: A valuable building block in the research and synthesis of protease inhibitors due to its structural similarity to natural substrates.
• Chemical Biology & Medicinal Chemistry: Utilized in the design and synthesis of molecular probes, tool compounds, and libraries for biological screening.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific custom synthesis projects.

Basic Information

Product Name	(S)-3-Boc-Amino-γ-Butyrolactone
CAS No.	104227-71-6
Molecular Formula	C9H15NO4
Molecular Weight	201.22 g/mol
Synonyms	(S)-3-[(tert-Butoxycarbonyl)amino]dihydro-2(3H)-furanone; (S)-3-(Boc-amino)butyrolactone; (S)-N-Boc-3-aminodihydro-2(3H)-furanone; (S)-3-(tert-Butoxycarbonylamino)butyrolactone; (S)-3-(Boc-Amino)-γ-butyrolactone; (S)-3-Amino-γ-butyrolactone tert-butylcarbamate; (S)-3-Boc-Aminodihydrofuran-2(3H)-one; (S)-3-(tert-Butyloxycarbonylamino)-γ-butyrolactone
EINECS	Contact for details

Quality Control

Our (S)-3-Boc-Amino-γ-Butyrolactone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity, and impurity profiles. Our quality management system is designed to meet the rigorous standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.