Description

1,3-Dioxolan-4-One, 5-[1-(Bromomethyl)-2-Nitroethyl]-2-(1,1-Dimethylet Hyl)-5-Methyl-, [2R-[2Alpha,5Beta(R*)]]- is a specialized chiral building block and advanced pharmaceutical intermediate of significant synthetic utility. Its complex molecular architecture, featuring a dioxolanone core with bromomethyl and nitroethyl substituents, makes it a valuable precursor for constructing stereochemically defined, nitrogen-containing heterocycles. This compound is primarily sought by research and development teams in the pharmaceutical and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules. Its defined stereochemistry at multiple centers is critical for applications requiring high enantiomeric purity.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel APIs, particularly those containing nitro or bromo functionalities for further derivatization.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce complex, multi-functionalized fragments into target molecules with high enantiocontrol.
• Medicinal Chemistry Research: Serves as a versatile scaffold in drug discovery programs for building diverse chemical libraries and probing structure-activity relationships (SAR).
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, agrochemicals, and other high-value, complex organic compounds.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of chiral target molecules.

Basic Information

Product Name	1,3-Dioxolan-4-One, 5-[1-(Bromomethyl)-2-Nitroethyl]-2-(1,1-Dimethylet Hyl)-5-Methyl-, [2R-[2Alpha,5Beta(R*)]]-
CAS No.	104194-08-3
Molecular Formula	C11H18BrNO5
Molecular Weight	324.17 g/mol
Synonyms	(2R,5R)-5-[(1R)-1-(Bromomethyl)-2-nitroethyl]-2-(tert-butyl)-2,5-dimethyl-1,3-dioxolan-4-one; (2R,5R)-5-[(1R)-1-(Bromomethyl)-2-nitroethyl]-2-(tert-butyl)-2,5-dimethyldioxolan-4-one; 5-[(1R)-1-(Bromomethyl)-2-nitroethyl]-2-(tert-butyl)-2,5-dimethyl-1,3-dioxolan-4-one, (2R,5R)-; [2R-[2α,5β(R*)]]-5-[1-(Bromomethyl)-2-nitroethyl]-2-(1,1-dimethylethyl)-5-methyl-1,3-dioxolan-4-one; 1,3-Dioxolan-4-one, 5-[1-(bromomethyl)-2-nitroethyl]-2-(1,1-dimethylethyl)-5-methyl-, [2R-[2α,5β(R*)]]-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material that meets high-purity specifications suitable for research and development applications. Certificates of Analysis (COA) detailing identity, purity (by HPLC), and impurity profiles are available upon request. Our quality management system ensures traceability and consistency for every batch supplied.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C (refrigerated) for long-term stability. Allow the container to reach ambient temperature before opening to prevent moisture condensation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.