Description

Didesmethyl Mifepristone CAS NO 104004-92-4 is a key pharmaceutical intermediate and metabolite of mifepristone, offering high purity and structural specificity for advanced research and development. This compound is critical for pharmacokinetic studies, metabolic pathway analysis, and the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard producers, and manufacturers of active pharmaceutical ingredients (APIs) requiring precise chemical building blocks.

Application

• Pharmaceutical Reference Standard: Serves as a certified analytical standard for the quantification and qualification of mifepristone and its metabolites in biological matrices.
• Metabolite Research: Essential for in-vitro and in-vivo studies investigating the metabolic pathways, pharmacokinetics, and pharmacodynamics of mifepristone.
• API Synthesis Intermediate: Used as a high-purity building block in the synthetic routes for developing steroid-based active pharmaceutical ingredients.
• Biochemical Research: Employed in receptor-binding assays and studies related to progesterone and glucocorticoid receptor antagonism.
• Quality Control & Method Development: Critical for developing and validating analytical methods (e.g., HPLC, LC-MS) in pharmaceutical quality control laboratories.

Basic Information

Product Name	Didesmethyl Mifepristone
CAS No.	104004-92-4
Molecular Formula	C₂₇H₃₃NO₃
Molecular Weight	419.56 g/mol
Synonyms	11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17α-(1-propynyl)-estra-4,9-dien-3-one; RU 42633; 11β-(4-N,N-Dimethylaminophenyl)-17β-hydroxy-17α-(prop-1-ynyl)-estra-4,9-dien-3-one; Mifepristone Didesmethyl Metabolite; 17α-(1-Propynyl)-11β-[4-(dimethylamino)phenyl]-17β-hydroxyestra-4,9-dien-3-one
EINECS	Contact for details

Quality Control

Our Didesmethyl Mifepristone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product is characterized and tested using advanced analytical techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.