Description

(2,2-Dimethyl-[1,3]Dioxolan-4-Yl)-Hydroxy-Acetic Acid Ethyl Ester is a versatile chiral building block and protected glycolic acid derivative essential for asymmetric synthesis. Its core value lies in providing a reactive ester functionality while protecting sensitive hydroxyl and carbonyl groups, enabling complex multi-step syntheses with high stereochemical control. This compound is primarily needed by research and development chemists and process scale manufacturers in the pharmaceutical and fine chemical industries for constructing active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of various drug candidates, particularly in antiviral, antibacterial, and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Used in the preparation of enantiomerically pure compounds, leveraging its protected diol moiety for stereoselective transformations.
• Natural Product Synthesis: Serves as a building block for complex natural products and bioactive molecules requiring specific stereocenters.
• Peptidomimetics & Prodrug Development: Employed to introduce ester-linked, bioreversible protecting groups or to modify peptide backbones.
• Ligand & Catalyst Preparation: Useful in the synthesis of chiral ligands and organocatalysts for catalytic asymmetric reactions.
• Polymer Chemistry: Can act as a monomer or co-monomer for specialty polymers requiring controlled degradation or specific functional groups.
• Agrochemical Synthesis: Intermediate in the production of certain chiral herbicides, fungicides, and plant growth regulators.
• Flavor & Fragrance Industry: Potential intermediate for creating specific chiral aroma chemicals and esters.

Basic Information

Product Name	(2,2-Dimethyl-[1,3]Dioxolan-4-Yl)-Hydroxy-Acetic Acid Ethyl Ester
CAS No.	103795-12-6
Molecular Formula	C9H16O5
Molecular Weight	204.22 g/mol
Synonyms	Ethyl (2,2-Dimethyl-1,3-dioxolan-4-yl)hydroxyacetate; Ethyl (R,S)-2,2-Dimethyl-1,3-dioxolane-4-hydroxyacetate; Ethyl 2-Hydroxy-2-((2,2-dimethyl-1,3-dioxolan-4-yl))acetate; Acetic acid, 2-((2,2-dimethyl-1,3-dioxolan-4-yl))-2-hydroxy-, ethyl ester; Ethyl (2,2-Dimethyl-1,3-dioxolan-4-yl)(hydroxy)acetate; Protected Glycolic Acid Ethyl Ester; Dioxolane Acetate Ester
EINECS	Contact for details

Quality Control

Our (2,2-Dimethyl-[1,3]Dioxolan-4-Yl)-Hydroxy-Acetic Acid Ethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.