Description

3-Trimethylsilyl-4-Pentenoicacid CAS NO 103681-20-5 is a versatile organosilicon building block featuring a reactive terminal alkene and a carboxylic acid group, protected by a trimethylsilyl moiety. This unique bifunctional structure makes it a valuable intermediate for synthesizing complex molecules in pharmaceutical and advanced material research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel compounds and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry projects targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its reactive sites for structural diversification.
• Polymer & Material Science: Serves as a functional monomer or cross-linking agent in the development of specialty silicones, coatings, and advanced polymeric materials.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, cycloadditions, and other transformations to introduce both silyl-protected acid and olefin functionalities into target molecules.
• Ligand & Catalyst Development: Useful precursor for creating novel ligands and organometallic complexes used in homogeneous catalysis.
• Peptide & Conjugate Chemistry: The carboxylic acid group allows for coupling to amines or alcohols, useful in bioconjugation and peptide mimetic research.

Basic Information

Product Name	3-Trimethylsilyl-4-Pentenoicacid
CAS No.	103681-20-5
Molecular Formula	C9H18O2Si
Molecular Weight	186.33 g/mol
Synonyms	4-Pentenoic acid, 3-(trimethylsilyl)-; 3-(Trimethylsilyl)-4-pentenoic acid; 3-Trimethylsilylpent-4-enoic acid; (3-Trimethylsilylpent-4-enoic acid); 103681-20-5; TMS-Protected 4-Pentenoic Acid; 3-TMS-4-pentenoic acid
EINECS	Contact for details

Quality Control

Our 3-Trimethylsilyl-4-Pentenoicacid is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support cGMP and ISO 9001 standards for manufacturing, ensuring reliable supply for critical pharmaceutical and chemical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.