Description

o-(tert-Butyldiphenylsilyl)Hydroxylamine is a specialized organosilicon-protected hydroxylamine derivative, a crucial reagent in modern synthetic organic chemistry. Its primary value lies in its role as a versatile amine-protecting group and a key building block for the synthesis of complex nitrogen-containing molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it facilitates the controlled introduction of hydroxylamine functionality.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for the preparation of oxime and hydroxamic acid derivatives, which are important pharmacophores in drug discovery.
• Peptide and Protein Modification: Used for the site-specific introduction of hydroxylamine groups into biomolecules for conjugation or study.
• Polymer Chemistry: Serves as a functional monomer or chain-transfer agent in the synthesis of specialty polymers with amine functionality.
• Agrochemical Development: Intermediate in the synthesis of novel herbicides, fungicides, and plant growth regulators containing N-O bonds.
• Material Science Research: Employed in surface functionalization and the creation of siloxane-based hybrid materials.
• Organic Synthesis Reagent: Acts as a protected source of nucleophilic hydroxylamine for the synthesis of heterocycles and other complex organic targets.

Basic Information

Product Name	o-(tert-Butyldiphenylsilyl)Hydroxylamine
CAS No.	103587-51-5
Molecular Formula	C16H21NOSi
Molecular Weight	271.43 g/mol
Synonyms	N-(tert-Butyldiphenylsilyl)hydroxylamine; O-(Tert-Butyldiphenylsilyl)hydroxylamine; Hydroxylamine, O-[1,1-dimethylethyl)diplenylsilyl]-; TBDPs-NHOH; tert-Butyldiphenylsilyl hydroxylamine; N-(tert-Butyldiphenylsilyl)-NHOH; O-TBDPS-hydroxylamine; N-Hydroxy-1,1-dimethylethyl-N-(diphenylsilyl)amine
EINECS	Contact for details

Quality Control

Our o-(tert-Butyldiphenylsilyl)Hydroxylamine is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity and identity. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.