Description

6-(Trimethylsilyl)Hex-5-Yn-1-Ol is a versatile organosilicon building block featuring both a terminal alkyne and a protected alcohol functional group. This bifunctional nature makes it a valuable intermediate for constructing complex molecular architectures via click chemistry and other coupling reactions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for applications ranging from drug discovery to polymer synthesis.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs) and bioactive molecules via Sonogashira, Huisgen cycloaddition, and other cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel pesticides, herbicides, and plant growth regulators that require silicon-containing alkyne motifs.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent for creating specialty polymers, dendrimers, and silicon-based hybrid materials with tailored properties.
• Liquid Crystal & OLED Materials: Employed in the synthesis of advanced organic electronic materials, where the silyl-protected alkyne unit aids in molecular alignment and stability.
• Proteomics & Bioconjugation: Acts as a linker or tag in bioconjugation strategies for labeling proteins, peptides, and other biomolecules.
• Organic Synthesis & Catalysis: A versatile reagent for constructing complex natural products and as a ligand precursor in organometallic catalysis.

Basic Information

Product Name	6-(Trimethylsilyl)Hex-5-Yn-1-Ol
CAS No.	103437-52-1
Molecular Formula	C9H18OSi
Molecular Weight	170.33 g/mol
Synonyms	5-Hexyn-1-ol, 6-(trimethylsilyl)-; 6-(Trimethylsilyl)-5-hexyn-1-ol; 6-Trimethylsilylhex-5-yn-1-ol; TMS-Hexynol; (5-Hydroxypent-1-yn-1-yl)trimethylsilane; Trimethyl((5-hydroxypent-1-yn-1-yl))silane
EINECS	Contact for details

Quality Control

Our production of 6-(Trimethylsilyl)Hex-5-Yn-1-Ol adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.