Description

Carbamic Acid, [1-[[(2,5-Dioxo-1-Pyrrolidinyl)Oxy]Carbonyl]Propyl]-, 1,1-Dimethylethyl Ester, (S)- is a high-purity, chiral chemical building block of significant importance in advanced organic synthesis. This compound is valued for its role as a protected amino acid derivative, enabling the controlled construction of complex peptide and small molecule architectures. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in the fields of peptide-based drugs and targeted biologics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and peptide-based therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid derivative to introduce specific chiral centers.
• Bioconjugation Chemistry: Serves as a reagent for the site-specific modification of proteins, antibodies, and other biomolecules, leveraging its active ester functionality.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) group provides orthogonal protection for amines in multi-step synthetic sequences.
• Research & Development: Employed in medicinal chemistry for the discovery and optimization of new drug candidates with defined stereochemistry.
• Linker Molecule: Can be utilized in the development of antibody-drug conjugates (ADCs) and other targeted drug delivery systems.

Basic Information

Product Name	Carbamic Acid, [1-[[(2,5-Dioxo-1-Pyrrolidinyl)Oxy]Carbonyl]Propyl]-, 1,1-Dimethylethyl Ester, (S)-
CAS No.	103290-07-9
Molecular Formula	C13H20N2O6
Molecular Weight	300.31 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)butanoic acid N-hydroxysuccinimide ester; Boc-L-2-Aminobutyric acid N-succinimidyl ester; Boc-L-Abu-OSu; N-Boc-L-2-Aminobutyric acid N-hydroxysuccinimide ester; N-(tert-Butoxycarbonyl)-L-2-aminobutyric acid succinimidyl ester; N-Boc-L-2-aminobutyric acid OSuc ester; N-Boc-L-Abu-OSu; L-2-Aminobutyric acid, N-[(1,1-dimethylethoxy)carbonyl]-, 2,5-dioxo-1-pyrrolidinyl ester
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [1-[[(2,5-Dioxo-1-Pyrrolidinyl)Oxy]Carbonyl]Propyl]-, 1,1-Dimethylethyl Ester, (S)- adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent hydrolysis of the active ester. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.