Description

(1R,4R)-4-((tert-Butyldimethylsilyl)Oxy)Cyclohexan-1-Ol is a high-purity, chiral protected diol intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a key building block for constructing complex, stereochemically defined molecules, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for producing active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapies.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce the (1R,4R) cyclohexane scaffold into target molecules, enabling the production of enantiomerically pure compounds.
• Natural Product Synthesis: Serves as a starting material or intermediate in the total synthesis of natural products with complex polycyclic structures.
• Agrochemical Research: Used in the development of novel, chiral pesticides and herbicides where specific stereochemistry is crucial for biological activity.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric catalysis.
• Material Science: Potential monomer or cross-linker for creating specialized polymers with defined stereochemistry and properties.

Basic Information

Product Name	(1R,4R)-4-((tert-Butyldimethylsilyl)Oxy)Cyclohexan-1-Ol
CAS No.	103202-63-7
Molecular Formula	C12H26O2Si
Molecular Weight	230.42 g/mol
Synonyms	(1R,4R)-4-[(tert-Butyldimethylsilyl)oxy]cyclohexanol; (1R,4R)-4-(tert-Butyldimethylsiloxy)cyclohexan-1-ol; trans-4-(tert-Butyldimethylsilyloxy)cyclohexanol (enantiomer); (1R,4R)-4-(TBDMSO)Cyclohexanol; (1R,4R)-TBDMS-protected cyclohexanediol; (1R,4R)-Cyclohexane-1,4-diol 4-tert-butyldimethylsilyl ether; (1R,4R)-4-O-TBDMS-cyclohexanol
EINECS	Contact for details

Quality Control

Our (1R,4R)-4-((tert-Butyldimethylsilyl)Oxy)Cyclohexan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high enantiomeric purity and chemical identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications for assay, enantiomeric excess, and impurity profiles. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliable and consistent performance in your critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.