Description

2-Naphthyl-2,3,4-Tri-o-Acetyl-β-D-Glucuronic Acid Methyl Ester is a key protected glucuronide derivative used as a critical synthetic intermediate and analytical standard. This compound matters for its role in the synthesis of complex glycoconjugates and as a reference material in metabolic and enzymatic studies. It is primarily needed by research institutions and pharmaceutical companies engaged in drug metabolism, prodrug development, and advanced carbohydrate chemistry.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of drug metabolites and targeted prodrugs.
• Biochemical Research: Used as a substrate or standard in enzymatic assays, particularly for glucuronosyltransferase activity studies.
• Glycoconjugate Synthesis: Acts as a protected glucuronic acid donor for the chemical synthesis of complex oligosaccharides and glycoconjugates.
• Analytical Reference Standard: Employed as a high-purity standard in HPLC, LC-MS, and NMR for method development and quantification in metabolic profiling.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to modify the pharmacokinetic properties of lead compounds.
• Academic Research: Fundamental tool for investigating glucuronidation pathways and carbohydrate-based chemical biology.

Basic Information

Product Name	2-Naphthyl-2,3,4-Tri-o-Acetyl-β-D-Glucuronic Acid Methyl Ester
CAS No.	102848-86-2
Molecular Formula	C26H26O11
Molecular Weight	514.48 g/mol
Synonyms	Methyl (2,3,4-tri-O-acetyl-β-D-glucopyranuronosyl)-(1→?)-2-naphthyl; 2-Naphthyl 2,3,4-tri-O-acetyl-β-D-glucopyranosiduronic acid methyl ester; β-D-Glucuronic acid, 2-naphthyl 2,3,4-triacetate, methyl ester; 2-Naphthyl β-D-glucopyranosiduronic acid, 2,3,4-triacetate, methyl ester; Glucuronic acid methyl ester triacetate naphthyl derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 2-Naphthyl-2,3,4-Tri-o-Acetyl-β-D-Glucuronic Acid Methyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with research and development grade standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.