Description

(R)-5-(tert-Butyldiphenylsiloxymethyl)Dihydro-2(3H)Furanone CAS NO 102717-29-3 is a high-value chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex bioactive molecules, particularly in the development of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for applications requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used as a building block in stereoselective organic synthesis to introduce specific chiral centers.
• Agrochemical Research: Intermediate in the development of novel chiral pesticides and herbicides.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high optical purity.
• Academic & R&D: Valuable reagent for methodological development in organic chemistry and catalysis research.
• Process Chemistry: Serves as a starting material or intermediate in scalable process development for commercial manufacturing.

Basic Information

Product Name	(R)-5-(tert-Butyldiphenylsiloxymethyl)Dihydro-2(3H)Furanone
CAS No.	102717-29-3
Molecular Formula	C21H26O3Si
Molecular Weight	354.52 g/mol
Synonyms	(R)-5-[(tert-Butyldiphenylsilyl)oxy]methyl]dihydrofuran-2(3H)-one; (R)-γ-Butyrolactone, 5-[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-; (R)-5-((tert-Butyldiphenylsilyloxy)methyl)dihydrofuran-2(3H)-one; (R)-TBDPS-protected 5-hydroxymethyl butyrolactone; (3R)-5-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]methyl]-2(3H)-furanone; (R)-5-(tert-Butyldiphenylsiloxymethyl)-γ-butyrolactone; (R)-TBDPSO-methyl-γ-butyrolactone
EINECS	Contact for details

Quality Control

Our (R)-5-(tert-Butyldiphenylsiloxymethyl)Dihydro-2(3H)Furanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with customer specifications and industry standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.