Description

(E)-1-[4-(4-Amino-6,7-Dimethoxy-Quinazolin-2-Yl)Piperazin-1-Yl]-3-(4-Azidophenyl)Prop-2-En-1-One is a high-purity, advanced pharmaceutical intermediate designed for research and development in targeted drug discovery. This compound is valued for its role as a key building block in the synthesis of novel therapeutic agents, particularly those targeting specific enzymatic pathways. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on oncology and kinase inhibitor development.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel quinazoline-based kinase inhibitors for targeted cancer therapies.
• Bioconjugation & Probe Development: The azido functional group enables its use in "click chemistry" reactions for labeling biomolecules, creating fluorescent probes, or developing antibody-drug conjugates (ADCs).
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of drug candidates.
• Biochemical Assay Development: Used in the development of high-throughput screening assays to identify and characterize new enzyme inhibitors.
• Academic & Institutional R&D: Employed in fundamental research exploring new mechanisms of action and signaling pathways in disease models.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry's drug discovery pipeline.

Basic Information

Product Name	(E)-1-[4-(4-Amino-6,7-Dimethoxy-Quinazolin-2-Yl)Piperazin-1-Yl]-3-(4-Azidophenyl)Prop-2-En-1-One
CAS No.	102714-70-5
Molecular Formula	C24H25N9O3
Molecular Weight	487.52 g/mol
Synonyms	4-Azidophenyl (E)-1-[4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-propen-1-one; (E)-1-(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)-3-(4-azidophenyl)prop-2-en-1-one; 4-Azidocinnamoyl Piperazinyl Quinazoline Derivative; Azido-PEG-Cinnamoyl-Piperazinyl-Quinazoline; Kinase Inhibitor Intermediate with Azide Handle; CAS 102714-70-5
EINECS	Contact for details

Quality Control

Our (E)-1-[4-(4-Amino-6,7-Dimethoxy-Quinazolin-2-Yl)Piperazin-1-Yl]-3-(4-Azidophenyl)Prop-2-En-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.