Description

Ethyl (E)-2,3-Difluoro-3-Phenyl-2-Propenoate is a high-value fluorinated building block and α,β-unsaturated ester. This compound is strategically important for the synthesis of complex molecules due to its reactive difluoroalkene moiety, which serves as a versatile handle for further functionalization. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, including protease inhibitors and kinase inhibitors, where fluorine atoms enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the difluoroalkene group to modulate biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or precursor for synthesizing specialty polymers and advanced materials with unique surface properties or optical characteristics.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, cycloadditions, and nucleophilic additions to construct complex, fluorinated organic frameworks in academic and industrial R&D settings.
• Ligand and Catalyst Development: Useful for preparing novel fluorinated ligands for metal catalysis, which can improve reaction selectivity and efficiency in fine chemical manufacturing.

Basic Information

Product Name	Ethyl (E)-2,3-Difluoro-3-Phenyl-2-Propenoate
CAS No.	102676-04-0
Molecular Formula	C11H10F2O2
Molecular Weight	212.19 g/mol
Synonyms	(E)-Ethyl 2,3-Difluoro-3-phenylacrylate; Ethyl (E)-α,β-Difluoro-β-phenylacrylate; 2-Propenoic acid, 2,3-difluoro-3-phenyl-, ethyl ester, (E)-; Ethyl (E)-2,3-Difluorocinnamate; 102676-04-0; (E)-2,3-Difluoro-3-phenyl-2-propenoic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl (E)-2,3-Difluoro-3-Phenyl-2-Propenoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (GC/HPLC)	≥ 98.0% (E-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.