Description

Tris (o-Tbdms)3 CAS NO 102522-47-4 is a specialized organosilicon protecting group reagent, specifically the tris(o-tert-butyldimethylsilyl) derivative. This compound is critically important in advanced organic synthesis, particularly in the pharmaceutical and agrochemical industries, where it provides robust protection for sensitive functional groups under demanding reaction conditions. It is primarily needed by research chemists and process development scientists working on complex multi-step syntheses, such as those for active pharmaceutical ingredients (APIs), fine chemicals, and novel materials.

Application

• Protecting Group Reagent: Used for the selective protection of hydroxyl groups in complex multi-step organic syntheses, offering superior stability compared to standard silyl ethers.
• Pharmaceutical Intermediate Synthesis: A key building block in the production of complex drug molecules, especially where acid- or base-labile intermediates are involved.
• Agrochemical Development: Employed in the synthesis of advanced pesticide and herbicide intermediates that require precise functional group manipulation.
• Peptide and Carbohydrate Chemistry: Facilitates the synthesis of complex natural products and biomolecules by protecting specific sites during chain elongation or modification.
• Material Science Research: Used in the development of novel silicon-containing polymers and advanced organic electronic materials.
• Process Chemistry Optimization: Valued for its predictable deprotection conditions, enabling scalable and reproducible manufacturing processes.

Basic Information

Product Name	Tris (o-Tbdms)3
CAS No.	102522-47-4
Molecular Formula	C30H72O3Si6
Molecular Weight	649.50 g/mol
Synonyms	Tris(o-tert-butyldimethylsilyl)3; Tris(ortho-tert-butyldimethylsilyl)3; 1,3,5-Tris[(tert-butyldimethylsilyl)oxy]benzene; TBDMS-protected phenol derivative; o-TBDMS protecting reagent; 1,3,5-Tris(2-((tert-butyldimethylsilyl)oxy)phenyl)benzene (related structural isomer); Silicon-based protecting group
EINECS	Contact for details

Quality Control

Our Tris (o-Tbdms)3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.