Description

cis-Dimethyl Pyrrolidine-3,4-Dicarboxylate Hydrochloride is a high-purity, protected pyrrolidine derivative serving as a critical chiral building block in advanced organic synthesis. This compound is essential for constructing complex molecular architectures with precise stereochemistry, enabling the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for process development and scale-up.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of proline-based drug candidates, including protease inhibitors, nootropic agents, and other bioactive molecules.
• Agrochemical Research: Used in the development of novel herbicides and pesticides where the pyrrolidine scaffold imparts specific biological activity.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and organocatalysts used in stereoselective transformations.
• Peptidomimetics: Integral for creating conformationally restricted peptide analogs in medicinal chemistry programs.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Scale-Up: A reliable starting material for contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects from gram to kilogram scale.

Basic Information

Product Name	cis-Dimethyl Pyrrolidine-3,4-Dicarboxylate Hydrochloride
CAS No.	102389-89-9
Molecular Formula	C9H16ClNO4
Molecular Weight	237.68 g/mol
Synonyms	Dimethyl (3R,4S)-1-[(benzyloxy)carbonyl]-3,4-pyrrolidinedicarboxylate hydrochloride (related protected form); 3,4-Pyrrolidinedicarboxylic acid, dimethyl ester, hydrochloride, cis-; cis-Dimethyl 3,4-pyrrolidinedicarboxylate hydrochloride; Methyl (3R,4S)-3,4-pyrrolidinedicarboxylate hydrochloride; Proline derivative, dimethyl ester HCl salt; Pyrrolidine-3,4-dicarboxylic acid dimethyl ester hydrochloride (cis-); Chiral pyrrolidine diester hydrochloride
EINECS	Contact for details

Quality Control

Every batch of cis-Dimethyl Pyrrolidine-3,4-Dicarboxylate Hydrochloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) including chiral purity, assay, and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (cis-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.