Description

4-(tert-Butyl-Dimethyl-Silanyloxy)-But-2-Ynoic Acid is a specialized silyl-protected alkyne carboxylic acid derivative, serving as a versatile and high-value synthetic building block in advanced organic chemistry. Its core value lies in enabling precise molecular construction, particularly in the synthesis of complex pharmaceuticals and novel materials where controlled reactivity and functional group protection are paramount. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for sophisticated synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing complex molecular scaffolds via Sonogashira and other cross-coupling reactions.
• Peptide Mimetics & Conjugation: Used to introduce alkyne handles for "click chemistry" (e.g., CuAAC) in bioconjugation, enabling the labeling and modification of peptides, proteins, and other biomolecules.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and plant growth regulators that require alkyne-functionalized intermediates.
• Material Science Research: Acts as a monomer or functionalization agent in the development of advanced polymers, dendrimers, and metal-organic frameworks (MOFs) with tailored properties.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized phosphine or N-heterocyclic carbene (NHC) ligands used in homogeneous catalysis.
• Academic & Contract Research: A critical reagent for methodology development and exploring new synthetic pathways in academic laboratories and CROs (Contract Research Organizations).

Basic Information

Item	Details
Product Name	4-(tert-Butyl-Dimethyl-Silanyloxy)-But-2-Ynoic Acid
CAS No.	102245-65-8
Molecular Formula	C12H22O3Si
Molecular Weight	242.39 g/mol
Synonyms	4-[(tert-Butyldimethylsilyl)oxy]but-2-ynoic acid; 4-(TBDMSO)but-2-ynoic Acid; 4-(tert-Butyldimethylsiloxy)-2-butynoic Acid; 2-Butynoic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-; 4-(Tert-butyldimethylsilyloxy)but-2-ynoic acid; TBDMS-protected butynoic acid; 4-(TBSO)but-2-ynoic Acid
EINECS	Contact for details

Quality Control

Our production of 4-(tert-Butyl-Dimethyl-Silanyloxy)-But-2-Ynoic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support cGMP compliance for pharmaceutical applications and can provide material manufactured under ISO 9001 quality systems. Certificates of Analysis (COA) are available upon request and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.