Description

n-Boc-cis-4-Hydroxy-L-Proline Methyl Ester is a protected amino acid derivative that serves as a crucial chiral building block in organic synthesis. This compound is essential for the efficient and stereoselective construction of complex peptide-based molecules and peptidomimetics. It is primarily utilized by pharmaceutical and biotechnology R&D teams for the development of new therapeutic agents, including protease inhibitors and other bioactive compounds.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of novel drug candidates, particularly those targeting proteases and other enzymes.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce constrained proline analogs, influencing peptide backbone conformation and stability.
• Bioconjugation & Probe Development: Employed in the preparation of labeled peptides and molecular probes for biochemical and diagnostic research.
• Chemical Biology Research: Facilitates the study of protein-protein interactions and enzyme mechanisms through the incorporation of modified proline residues.
• Combinatorial Chemistry: A valuable scaffold in libraries designed for high-throughput screening to discover new bioactive molecules.
• Academic & Industrial R&D: Serves as a fundamental research chemical in laboratories focused on medicinal chemistry and organic methodology development.

Basic Information

Product Name	n-Boc-cis-4-Hydroxy-L-Proline Methyl Ester
CAS No.	102195-79-9
Molecular Formula	C11H19NO5
Molecular Weight	245.27 g/mol
Synonyms	trans-4-Hydroxy-L-proline, 1-(1,1-dimethylethyl) 2-methyl ester; (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-pyrrolidinecarboxylic acid methyl ester; Methyl (2S,4R)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylate; Boc-4(R)-hydroxy-L-proline methyl ester; Boc-cis-4-hydroxy-L-proline methyl ester; (4R)-1-Boc-4-hydroxy-L-proline methyl ester; (2S,4R)-1-Boc-4-hydroxyproline methyl ester; L-Proline, 4-hydroxy-, 1-(1,1-dimethylethyl) 2-methyl ester, (4R)-
EINECS	Contact for details

Quality Control

Our n-Boc-cis-4-Hydroxy-L-Proline Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.