Description

L-Tyrosine, n-[(1,1-Dimethylethoxy)Carbonyl]-o-Ethyl-, Ethyl Ester CAS NO 101998-39-4 is a protected derivative of the essential amino acid L-Tyrosine, specifically engineered for advanced organic synthesis. This compound matters as a critical high-purity building block that enables the precise construction of complex peptides and bioactive molecules while protecting sensitive functional groups. It is primarily needed by pharmaceutical R&D teams, peptide synthesis specialists, and fine chemical manufacturers developing novel therapeutic agents and biochemical tools.

Application

• Pharmaceutical Intermediate: A key protected precursor in the multi-step synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate tyrosine residues while preventing unwanted side reactions.
• Biochemical Research: Serves as a specialized reagent for studying enzyme mechanisms, protein-protein interactions, and signal transduction pathways.
• Protecting Group Chemistry: The tert-butoxycarbonyl (Boc) and ethyl ester groups provide orthogonal protection, essential for complex, multi-functional molecule assembly.
• Labeled Compound Synthesis: A starting material for synthesizing isotopically labeled (e.g., C13, N15) tyrosine derivatives for metabolic and pharmacokinetic studies.
• Ligand and Probe Development: Utilized in creating fluorescent probes, affinity ligands, and molecular imaging agents targeting tyrosine kinase pathways.

Basic Information

Product Name	L-Tyrosine, n-[(1,1-Dimethylethoxy)Carbonyl]-o-Ethyl-, Ethyl Ester
CAS No.	101998-39-4
Molecular Formula	C18H27NO5
Molecular Weight	337.41 g/mol
Synonyms	N-Boc-O-Ethyl-L-tyrosine Ethyl Ester; Boc-Tyr(OEt)-OEt; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-[4-(ethoxy)phenyl]propanoic Acid Ethyl Ester; Ethyl N-(tert-Butoxycarbonyl)-O-ethyl-L-tyrosinate; Boc-L-Tyrosine(O-Ethyl)-O-Ethyl Ester; N-tert-Butoxycarbonyl-O-ethyl-L-tyrosine Ethyl Ester; L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-, O-ethyl-, ethyl ester
EINECS	Contact for details

Quality Control

Our L-Tyrosine derivative is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with exacting standards. Certificates of Analysis (COA) with full traceability are provided, confirming identity, potency, and impurity profiles. We support development with custom synthesis and scale-up capabilities under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]20/D: Specific range provided on COA
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.