Description

Methyl (S)-(-)-4-Bromo-3-tert-Butyldimethylsilyloxybutanoate CAS NO 101703-35-9 is a high-purity chiral building block and protected intermediate of significant synthetic utility. This compound is valued for its role in the stereoselective synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily sought by process chemists and researchers in the pharmaceutical, agrochemical, and fine chemical industries for constructing active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially for cardiovascular and central nervous system (CNS) targets.
• Asymmetric Synthesis: Utilized in stereocontrolled reactions to introduce the (S)-configured stereocenter into more complex molecular architectures.
• Natural Product Synthesis: Serves as a protected hydroxy acid derivative in the total synthesis of complex natural products with biological activity.
• Agrochemical Research: Employed in the development of chiral active ingredients for herbicides, fungicides, and insecticides.
• Peptidomimetics & Bioisosteres: Used to incorporate non-natural amino acid fragments or constrained analogs into peptide-based drug discovery programs.
• Chemical Biology Probes: Acts as a precursor for labeled or tagged molecules used to study biological pathways and enzyme mechanisms.

Basic Information

Product Name	Methyl (S)-(-)-4-Bromo-3-tert-Butyldimethylsilyloxybutanoate
CAS No.	101703-35-9
Molecular Formula	C11H23BrO3Si
Molecular Weight	311.29 g/mol
Synonyms	(S)-Methyl 4-bromo-3-((tert-butyldimethylsilyl)oxy)butanoate; Methyl (S)-4-Bromo-3-(tert-butyldimethylsiloxy)butyrate; (S)-(-)-Methyl 4-bromo-3-(tert-butyldimethylsilyloxy)butanoate; (S)-Methyl 4-bromo-3-[(1,1-dimethylethyl)dimethylsilyl]oxy-butanoate; TBDMS-protected (S)-4-Bromo-3-hydroxybutyric acid methyl ester; (S)-Methyl 4-bromo-3-(TBDMS-oxy)butanoate
EINECS	Contact for details

Quality Control

Our Methyl (S)-(-)-4-Bromo-3-tert-Butyldimethylsilyloxybutanoate is produced under strict quality management systems to ensure batch-to-batch consistency and high chemical purity, critical for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical purity, and identity confirmation. We adhere to cGMP principles where applicable to support our clients' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.