Description

2,4,6-Tri-tert-Butyl-n-(Trimethylsilyl)Aniline is a sterically hindered aniline derivative featuring both tert-butyl and trimethylsilyl protecting groups. This compound is a valuable advanced intermediate and protecting group reagent in sophisticated organic synthesis, particularly where extreme steric hindrance and moisture sensitivity are critical factors. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, especially those requiring protected amine functionalities.
• Ligand Precursor: Used in the preparation of sterically demanding ligands for catalysis, including those in transition metal complexes.
• Polymer Chemistry: Acts as a monomer or functionalization agent in the production of specialty polymers with tailored thermal or chemical resistance.
• Material Science Research: Employed in the development of organic electronic materials, such as hole-transport layers or molecular semiconductors.
• Agrochemical Synthesis: Functions as an intermediate in creating novel, high-performance crop protection agents.
• Academic & Industrial R&D: A crucial reagent for methodological development in organic chemistry, particularly in reactions involving sensitive organometallic species.

Basic Information

Product Name	2,4,6-Tri-tert-Butyl-n-(Trimethylsilyl)Aniline
CAS No.	101455-63-4
Molecular Formula	C21H39NSi
Molecular Weight	333.63 g/mol
Synonyms	N-(Trimethylsilyl)-2,4,6-tri-tert-butylaniline; 2,4,6-Tri-tert-butyl-N-(trimethylsilyl)benzenamine; Benzenamine, 2,4,6-tris(1,1-dimethylethyl)-N-(trimethylsilyl)-; N-Trimethylsilyl-2,4,6-tri-tert-butylaniline; 2,4,6-Tri-tert-butyl-N-trimethylsilylaniline; TBS-Protected 2,4,6-Tri-tert-butylaniline; TMS-2,4,6-Tri-tert-butylaniline
EINECS	Contact for details

Quality Control

Our 2,4,6-Tri-tert-Butyl-n-(Trimethylsilyl)Aniline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC, GC, and NMR, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.