Description

4-(2,3-Dichlorophenyl)-3-(Ethoxycarbonyl)-2-((2-Hydroxyethoxy)Methyl)-5-(Methoxycarbonyl)-6-Methyl-1,4-Dihydropyridine is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. This compound is valued for its role as a key synthetic precursor in the development of complex active pharmaceutical ingredients (APIs), particularly within the cardiovascular and neurological therapeutic areas. It is primarily sought by research institutions, custom synthesis houses, and large-scale pharmaceutical manufacturers engaged in innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel 1,4-dihydropyridine-based calcium channel blockers and other therapeutic agents.
• Drug Discovery & Development: Used in medicinal chemistry research for structure-activity relationship (SAR) studies and lead optimization programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.
• Chemical Research: Serves as a model compound in academic and industrial research focused on heterocyclic chemistry and asymmetric synthesis methodologies.
• Process Chemistry: Utilized for scaling up and optimizing synthetic routes for cost-effective and robust API manufacturing.

Basic Information

Product Name	4-(2,3-Dichlorophenyl)-3-(Ethoxycarbonyl)-2-((2-Hydroxyethoxy)Methyl)-5-(Methoxycarbonyl)-6-Methyl-1,4-Dihydropyridine
CAS No.	101411-53-4
Molecular Formula	C₂₀H₂₁Cl₂NO₆
Molecular Weight	442.29 g/mol
Synonyms	4-(2,3-Dichlorophenyl)-3-ethoxycarbonyl-2-[(2-hydroxyethoxy)methyl]-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine; 1,4-Dihydropyridine Derivative; DHP Intermediate; CAS 101411-53-4; 2-[(2-Hydroxyethoxy)methyl]-4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine; 3-Ethoxycarbonyl-5-methoxycarbonyl-2-((2-hydroxyethoxy)methyl)-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine
EINECS	Contact for details

Quality Control

Our 4-(2,3-Dichlorophenyl)-3-(Ethoxycarbonyl)-2-((2-Hydroxyethoxy)Methyl)-5-(Methoxycarbonyl)-6-Methyl-1,4-Dihydropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific client or regulatory standards (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); therefore, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.