Description

2-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Pyridine is a high-value organosilicon-protected pyridine derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a versatile protecting group for alcohols and as a key intermediate in the synthesis of complex pharmaceuticals and agrochemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-purity intermediates for multi-step synthetic routes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing pyridine or alcohol functionalities requiring selective protection.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the tert-butyldimethylsilyl (TBDMS) protecting group is employed.
• Peptide & Nucleoside Chemistry: Acts as a protective agent for hydroxyl groups during the synthesis of complex biomolecules like oligonucleotides and modified peptides.
• Material Science Precursor: Intermediate in the production of functionalized ligands for catalysts and novel organosilicon materials.
• Academic & Industrial R&D: A valuable reagent for method development and exploratory synthesis in medicinal chemistry and total synthesis projects.

Basic Information

Product Name	2-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Pyridine
CAS No.	101192-63-6
Molecular Formula	C12H21NOSi
Molecular Weight	223.39 g/mol
Synonyms	2-((tert-Butyldimethylsilyloxy)methyl)pyridine; 2-Pyridinemethanol, 1-(1,1-dimethylethyl)dimethylsilyl ether; 2-(TBDMS-oxymethyl)pyridine; 2-((Tert-butyldimethylsilyloxy)methyl)pyridine; 2-(((tert-Butyldimethylsilyl)oxy)methyl)pyridine; N/A
EINECS	Contact for details

Quality Control

Our 2-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) with full traceability are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.