Description

1H-Indene-1-Ethanol, 4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]octahydro-β,7a-dimethyl-, (βs,1R,3ar,4S,7ar)- is a high-purity, organosilicon-protected indene derivative with a defined stereochemistry, serving as a critical chiral building block in advanced organic synthesis. Its value lies in enabling the precise construction of complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty fine chemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for asymmetric synthesis and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel therapeutic agents, including steroids and other bioactive molecules.
• Asymmetric Catalysis Substrate: Used in stereoselective reactions to introduce specific chiral centers with high enantiomeric excess.
• Agrochemical Research: Serves as a precursor in the development of new pesticides and herbicides with optimized activity profiles.
• Material Science: Potential building block for creating specialized polymers or liquid crystals with unique optical properties.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial manufacturing of complex organic compounds.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic synthesis and total synthesis projects.

Basic Information

Product Name	1H-Indene-1-Ethanol, 4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]octahydro-β,7a-dimethyl-, (βs,1R,3ar,4S,7ar)-
CAS No.	100928-03-8
Molecular Formula	C19H36O2Si
Molecular Weight	324.58 g/mol
Synonyms	(1R,3aR,4S,7aR)-4-[(tert-Butyldimethylsilyl)oxy]octahydro-β,7a-dimethyl-1H-indene-1-ethanol; 4-[(tert-Butyldimethylsilyl)oxy]octahydro-β,7a-dimethyl-1H-indene-1-ethanol; TBDMS-protected indene ethanol derivative; (βs,1R,3Ar,4S,7Ar)-1H-Indene-1-ethanol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]octahydro-β,7a-dimethyl-; tert-Butyldimethyl((1R,3aR,4S,7aR)-1-(2-hydroxyethyl)octahydro-β,7a-dimethyl-1H-inden-4-yl)oxy)silane
EINECS	Contact for details

Quality Control

Our 1H-Indene-1-Ethanol derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.