Description

3-Ó3-(2-Bromoacetamido)Propylcarbamoyl]-Proxyl is a stable nitroxide free radical compound, specifically a proxyl derivative functionalized with a bromoacetamido group. This molecule is a critical spin label and spin trap used in electron paramagnetic resonance (EPR) spectroscopy for probing molecular structure, dynamics, and interactions in complex systems. It is essential for researchers and developers in advanced material science, structural biology, and pharmaceutical research who require precise tools for studying free radical processes and biomolecular conformation.

Application

• EPR/ESR Spectroscopy: As a site-directed spin label for studying protein folding, membrane protein dynamics, and nucleic acid structure.
• Polymer Science: For monitoring polymerization kinetics, studying polymer chain mobility, and characterizing cross-linking density in advanced materials.
• Bioconjugation & Probe Development: The reactive bromoacetamido moiety allows for specific covalent attachment to thiol groups (cysteine residues) in proteins and peptides.
• Oxidative Stress Research: Acting as a spin trap to detect and quantify short-lived reactive oxygen species (ROS) in biological and chemical systems.
• Pharmaceutical Research: Used in drug discovery to study drug-target interactions and the role of free radicals in disease mechanisms.
• Material Characterization: Investigating molecular order and dynamics in liquid crystals, lipid bilayers, and nanocomposites.

Basic Information

Product Name	3-Ó3-(2-Bromoacetamido)Propylcarbamoyl]-Proxyl, Free Radical
CAS No.	100900-11-6
Molecular Formula	C₁₄H₂₃BrN₃O₄
Molecular Weight	377.26 g/mol
Synonyms	3-Carbamoyl-2,2,5,5-tetramethyl-1-pyrrolidinyloxy, 3-[(2-Bromoacetamido)propyl] derivative; Proxyl bromoacetamide; 3-(3-((2-Bromoacetyl)amino)propylcarbamoyl)-2,2,5,5-tetramethyl-1-pyrrolidinyloxy; 3-Maleimido-PROXYL bromoacetamide derivative; Bromoacetamido-PROXYL spin label; 100900-11-6; Stable nitroxide radical
EINECS	Contact for details

Quality Control

Every batch of our 3-Ó3-(2-Bromoacetamido)Propylcarbamoyl]-Proxyl is synthesized and purified under controlled conditions to ensure the highest chemical purity and radical stability. Our products undergo rigorous quality testing, including HPLC for purity verification and EPR spectroscopy to confirm radical content and integrity. Certificates of Analysis (COA) detailing batch-specific data are available upon request, ensuring full traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation and maintain stability.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Identification (EPR)	Characteristic triplet signal
Purity (HPLC)	≥ 95%
Assay (EPR)	≥ 98% radical content
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, chloroform; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.